![]() The studies varied considerably in terms of types of participants, their diagnoses, the dose of betahistine and the length of time the drug was taken for, the study methods and the way any improvement in vertigo symptoms was measured. We judged the quality of evidence overall to be low. One study, at high risk of bias, included 72 people with benign paroxysmal positional vertigo (BPPV) and compared betahistine with placebo all patients also had particle repositioning manoeuvres. ![]() All studies with analysable data lasted three months or less. Sixteen studies including 953 people compared betahistine with placebo the studies were at high to unclear risk of bias. We included 17 studies, with a total of 1025 participants. This review examines whether betahistine is more effective than a placebo (sham medicine) at treating symptoms of vertigo from different causes in patients of any age. Betahistine is a drug that may work by improving blood flow to the inner ear. It is a commonly experienced symptom and can cause significant problems with carrying out normal activities. This type of dizziness is thought to originate in the inner ear balance organ or its connections to the brain. Vertigo is a symptom in which individuals experience a false sensation of movement. We looked for information on generic quality of life and falls, but none of the studies reported on these outcomes.ĭo patients suffering from vertigo from different causes benefit from the drug betahistine? Three studies looked at objective vestibular function tests as an outcome the numbers of participants were small, techniques of measurement very diverse and reporting details sparse, so analysis of this outcome was inconclusive. Sixteen per cent of patients from both the betahistine and the placebo groups withdrew (dropped out) from the studies (RR 0.96, 95% CI 0.65 to 1.42 481 participants eight studies). This result should be interpreted with caution as the test for statistical heterogeneity as measured by the I 2 value was high.Īdverse effects (mostly gastrointestinal symptoms and headache) were common but medically serious events in the study were rare and isolated: there was no difference in the frequency of adverse effects between the betahistine and placebo groups, where the rates were 16% and 15% respectively (weighted values, RR 1.03, 95% CI 0.76 to 1.40 819 participants 12 studies). Pooled data showed that the proportion of patients reporting an overall reduction in their vertigo symptoms was higher in the group treated with betahistine than the placebo group: risk ratio (RR) 1.30, 95% confidence interval (CI) 1.05 to 1.60 606 participants 11 studies). Using the GRADE system, we judged the quality of evidence overall to be low for two outcomes (proportion of patients with improvement and proportion with adverse events). The studies varied considerably in terms of types of participants, their diagnoses, the dose of betahistine and the length of time it was taken for, the study methods and the way any improvement in vertigo symptoms was measured. The majority were at high risk of bias, but in some the risk of bias was unclear. Sixteen studies including 953 people compared betahistine with placebo. Many medical conditions can lead to dizziness and any of its subcategories.We included 17 studies, with a total of 1025 participants 12 studies were published (567 patients) and five were unpublished (458 patients). Disequilibrium is usually not associated with nausea or vomiting, though it is a common type of dizziness. Disequilibriumĭisequilibrium is the sensation of being off balance and is most often characterized by frequent falls in a specific direction. It is different from syncope, which is the process of actually fainting. Presyncope is also known as lightheadedness, muscular weakness and feeling faint. It represents about 25 percent of all types of dizziness. People find vertigo to be very disturbing and severe vertigo can cause nausea and vomiting. Vertigo is described as the concept of spinning or having your surroundings spin around you. The following are specific types of dizziness: Vertigo Dizziness refers to an impairment in spatial perception and stability.
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